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Melatonin has been shown to have anti-inflammatory results, amongst a number of actions. Melatonin decreases tissue damage during inflammatory reactions by a variety of means. Hence melatonin, through its ability to directly feed on harmful free radicals, minimizes macromolecular damage in all body organs. The free radicals and responsive oxygen as well as nitrogen varieties recognized to be scavenged by melatonin include the extremely hazardous hydroxyl radical, peroxynitrite anion, as well as hypochlorous acid, to name a few. These representatives all add to the inflammatory response and associated tissue damage. In addition, melatonin has other means to decrease the damages resulting from swelling.
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