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It was the discovery of melatonin synthesis in endocrine organs, specifically the pineal gland, neural structures, and immunocompetent cells such as T lymphocytes, NK cells, and mast cells that set off the brand-new techniques to the unifield signal regulation of homeostasis, which, at the turn of the 21st century, cause the production of a brand-new essential biomedical technique - neuroimmunoendocrinology.
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