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It was the exploration of melatonin synthesis in endocrine organs, namely the pineal gland, neural structures, as well as immunocompetent cells such as T lymphocytes, NK cells, and also mast cells that activated the new techniques to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, bring about the development of a new integral biomedical discipline - neuroimmunoendocrinology.
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